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The Science of Cannabinoids

Cannabinoids are a class of chemical compounds that act upon cannabinoid receptors found in human and animal cells. CBD (Cannabidiol) is a type of phytocannabinoid – a cannabinoid that naturally occurs in some plants, including Hemp. Cannabinoid receptors are most concentrated in the human brain. Currently, there are two known types of cannabinoid receptors: CB1 and CB2. Further research has indicated that more exist; however, it has yet to be verified. When these chemical compounds act upon cannabinoid receptors, it alters the neurotransmitter release in the brain and signals the CB1 and CB2 receptors in their respective systems throughout the body. For example, CB1 receptors are found in the brain and the limbic system, while CB2 receptors are found in the immune system, primarily the spleen.  CB1 receptors affect respiratory and cardiovascular functions. CB2 receptors are responsible for anti-inflammatory functions.

The Endocannabinoid System (ECS) 

The Endocannabinoid System, which is found in the human and mammalian brain and throughout the entire body, communicates with cannabinoid compounds. The ECS is involved in a number of physiological processes including pain management, appetite, mood and memory.

The two primary receptors and drivers of the ECS are Cannabinoid receptors type 1 and 2 (aka. CB1 and CB2).  Based upon the interaction between the transmitter and receptor, a variety of responses in the post-synaptic cell may occur, such as excitation or inhibition. It is here where phytocannabinoid-rich products begin working, and where consumers begin to notice.  Cannabinoids act upon the CB1 and CB2 receptors and effect their respective systems.

Because of the ECS involvement in multiple systems, cannabinoid receptors are located throughout the body, in many different areas and organs. Cannabinoids stimulate this internal system and promote overall health and wellness, in all human and animals. International studies have favorably discussed the interaction cannabinoids may have with nausea and vomiting, seizure activity, psychosis disorders, inflammation, neurodegenerative disease, tumors, anxiety, depression, etc. We encourage our customers to do their own research and learn about their body's ECS and cannabinoid-response. There are ample resources now available online and in print. As our products are not regulated by the FDA, we can not make medical claims. Our products are not intended to diagnose, treat, cure, or prevent any disease.  

In the United States

Industrial hemp products are legal to cultivate in the United States because of The Agricultural Act of 2014, more commonly called the Farm Bill.  Previously, it was legal to import industrial hemp products; however, imported hemp products are not always subject to the necessary oversight to ensure high-quality products.   

Many countries, including and outside of the United States, have found much success in their studies of cannabinoids. Further research and legislation changes are needed in the U.S. to further our clinical process. The US government holds a patent on cannabinoids, as filed through the Department of Health and Human Services. “Cannabinoids as antioxidants and neuroprotectants” was filled as patent #US6630507 in 1999, and was further featured in various publications between 1999 and 2007. However, there has been little to no action from the federal government regarding their knowledge of this plant's medicinal capabilities.

Where the US Goes from Here

It is vital that the American government take steps to provide legal outlines by which hemp can be further studied. We need more transparency and medical research so that we can separate fact from fiction, and educate our general public through positive discourse.  We are confident that the best medical professionals in the United States could unlock the full potential of hemp and it's naturally occurring cannabinoids. Please contact your state representatives, sign the petitions, and become an advocate for better legislation and medical research on the cannabis plant, including hemp. 


Holistic Hemp Co. || 100% natural, cannabinoid-rich, American hemp oil.